Supplementary material
The web page http://www.marmosetbrain.org/cell_density contains the most recent versions of the supplementary materials for the article:Neuronal density across the entire cerebral cortex of the marmoset monkey
Abstract
Using stereological analysis of NeuN-stained sections, we investigated neuronal density in 116 cytoarchitectural areas of the marmoset cortex. Our results revealed that estimates of average neuronal density encompassed a greater than threefold range, from a maximum (>150,000 neurons/ mm3) in the primary visual cortex to a minimum (~50,000 neurons/ mm3) in the piriform complex. In agreement with previous studies, there was a trend for density values to decrease from posterior to anterior cortical areas, but we also observed significant local gradients, which added complexity to this pattern. For example, in the frontal lobe, neuronal density was lowest among motor and premotor areas, and increased towards the frontal pole. Likewise, in both auditory cortex and somatosensory areas, it increased from caudal to rostral subdivisions. In general, anterior cingulate, insular and ventral temporal proisocortical and periallocortical areas were characterized by low neuronal densities. Analysis across the thickness of the cortex revealed greater laminar variation in occipital, parietal and inferior temporal areas, in comparison with other regions. These results are compatible with a common pattern of variation in neuronal density among primates, and suggest that neuronal density values in the adult cortex result from a complex interaction of developmental/evolutionary determinants and functional requirements.
PMID: 30357325 DOI: 10.1093/cercor/bhy263
Cell Density Image Download
- Dorsolateral prefrontal cortex
- Ventrolateral prefrontal cortex
- Orbitofrontal cortex
- Medial prefrontal cortex
- Motor and premotor cortex
- Area 6 of cortex, dorsorostral part (A6DR) ⬆
- Area 6 of cortex, ventral, part b (A6Vb) ⬆
- Area 6 of cortex, ventral, part a (A6Va) ⬆
- Area 8 of cortex, caudal part (A8C) ⬆
- Area 6 of cortex, medial (supplementary motor) part (A6M) ⬆
- Area 6 of cortex, dorsocaudal part (A6DC) ⬆
- Area 4 of cortex, part c (primary motor) (A4c) ⬆
- Area 4 of cortex, parts a and b (primary motor) (A4ab) ⬆
- Area 6 of cortex, dorsorostral part (A6DR) ⬆
- Insula and rostral lateral sulcus cortex
- Somatosensory cortex
- Secondary somatosensory cortex, parietal rostral area (S2PR) ⬆
- Area 3a of cortex (somatosensory) (A3a) ⬆
- Secondary somatosensory cortex, parietal ventral area (S2PV) ⬆
- Area 3b of cortex (somatosensory) (A3b) ⬆
- Secondary somatosensory cortex, internal part (S2I) ⬆
- Secondary somatosensory cortex, external part (S2E) ⬆
- Areas 1 and 2 of cortex (Area 1 and 2) ⬆
- Secondary somatosensory cortex, parietal rostral area (S2PR) ⬆
- Auditory cortex
- Rostrotemporal lateral area (RTL) ⬆
- Rostrotemporal area (RT) ⬆
- Rostral parabelt area (RPB) ⬆
- Rostrotemporal medial area (RTM) ⬆
- Rostral auditory area (R) ⬆
- Rostromedial area (RM) ⬆
- Anterolateral area (AL) ⬆
- Primary auditory area (A1) ⬆
- Caudomedial area (CM) ⬆
- Caudal parabelt area (CPB) ⬆
- Middle lateral area (ML) ⬆
- Caudolateral area (CL) ⬆
- Rostrotemporal lateral area (RTL) ⬆
- Lateral and inferior temporal cortex
- Temporopolar proisocortex (TPPro) ⬆
- Superior temporal rostral area (cortex) (STR) ⬆
- Temporal area te1 (TE1) ⬆
- Temporo-parieto-occipital association area (TPO(STP)) ⬆
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- Retroinsular area (cortex) (ReI) ⬆
- Temporal area te2 (TE2) ⬆
- Area PGa and IPa (fundus of superior temporal ventralarea) (PGa(IPa)) ⬆
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- Temporoparietal transitional area (TPt) ⬆
- Temporal area te3 (TE3) ⬆
- Temporal area te, occipital part (TEO) ⬆
- Temporopolar proisocortex (TPPro) ⬆
- Ventral temporal cortex
- Posterior cingulate, medial and retrosplenial cortex
- Posterior parietal cortex
- Parietal area pf (cortex) (PF) ⬆
- Parietal area pe (PE) ⬆
- Parietal area pfg (cortex) (PFG) ⬆
- Area 31 of cortex (A31) ⬆
- Anterior intraparietal area of cortex (AIP) ⬆
- Parietal area pg (PG) ⬆
- Parietal area pe, caudal part (PEC) ⬆
- Ventral intraparietal area of cortex (VIP) ⬆
- Lateral intraparietal area of cortex (LIP) ⬆
- Parietal area pg, medial part (cortex) (PGM) ⬆
- Visual area 6a (posterior parietal medial area) (V6a) ⬆
- Occipito-parietal transitional area of cortex (OPt) ⬆
- Medial intraparietal area of cortex (MIP) ⬆
- Parietal area pf (cortex) (PF) ⬆
- Visual cortex
- Medial superior temporal area of cortex (MST) ⬆
- Fundus of superior temporal sulcus area of cortex (FST) ⬆
- Visual area 5 (middle temporal area) (V5) ⬆
- Visual area 4, transitional part (middle temporal crescent) (V4T) ⬆
- Area 19 of cortex, medial part (A19M) ⬆
- Visual area 3a (dorsoanterior area) (V3a) ⬆
- Visual area 4 (ventrolatereral anterior area) (V4) ⬆
- Visual area 6 (dorsomedial area) (V6) ⬆
- Area 19 of cortex, dorsointermediate part (A19DI) ⬆
- Visual area 3 (ventrolateral posterior area) (V3) ⬆
- Visual area 2 (V2) ⬆
- Primary visual cortex (V1) ⬆
- Medial superior temporal area of cortex (MST) ⬆
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Australian Research Council
Australian Research Council
Center of Excellence for Integrative Brain Function
Monash University
conducted in collaboration with
the Laboratory of Neuroinformatics at
the Nencki Institute of Experimental Biology;
Warsaw, Poland.
International Neuroinformatics Coordinating Facility
Seed Funding Grant
Cold Spring Habor Laboratory